2021

Bae M; Mevers E; Pishchany G; Whaley SG; Rock CO; Andes DR; Currie CR; Pupo MT; Clardy J. (2021) Chemical Exchanges between Multilateral Symbionts. Organic Letters, 23 (5): 1648–1652. https://doi.org/10.1021/acs.orglett.1c00068 

Fukuda TTH; Helfrich EJN; Mevers E; Melo WGP; Van Arnam EB; Andes DR; Currie CR; Pupo MT; Clardy J. (2021) Specialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis. ACS Central Science 7 (2): 292–299. https://doi.org/10.1021/acscentsci.0c00978.

Fukuda TTH; Pereira, CF; Melo WGP; Menegatti C; Andrade PHM; Groppo M; Lacava PT; Currie CR; Pupo MT. (2021) Insights into the Ecological Role of Pseudomonas spp. in an Ant-plant Symbiosis. Frontiers in Microbiology 12: Article 621274. https://doi.org/10.3389/fmicb.2021.621274

De Paula GT; Menezes C; Pupo MT; Rosa CA. (2021) Stingless bees and microbial interactions. Current Opinion in Insect Science 44: 41-47. https://doi.org/10.1016/j.cois.2020.11.006

Ortega HE; Lourenzon VB; Chevrette MG; Ferreira LLG; Ramos-Alvarenga RF; Melo WGP; Venâncio T; Currie CR; Andricopulo AD; Bugni TS; Pupo MT. (2021) Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311. Bioorganic & Medicinal Chemistry, 32: 116016. https://doi.org/10.1016/j.bmc.2021.116016

Menegatti C; Fukuda TTH; Pupo MT. (2021) Chemical Ecology in Insect-Microbe Interactions in the Neotropics. Planta Medica 87(01/02): 38-48. https://doi.org/ 10.1055/a-1229-9435

 

2020

Khadempour L; Fan H; Keefover-Ring K; Carlos-Shanley C; Nagamoto NS; Dam MA; Pupo MT; Currie CR. (2020) Metagenomics reveals diet-specific specialization of bacterial communities in fungus gardens of grass-and dicot-cutter ants. Frontiers in Microbiology, 11: 570770. https://doi.org/10.3389/fmicb.2020.570770

Ries LNA, Pardeshi L, Dong Z, Tan K, Steenwyk JL, Colabardini AC, Ferreira Filho JA, Castro PA, Silva LP, Preite NW, Almeida F, Assis LJ, Santos RAC, Bowyer P, Bromley M, Owens RA, Doyle S, Demasi M, Rodríguez-Hernández DC, Netto LES, Pupo MT, Rokas A, Loures FV, Wong KH, Goldman GH. (2020) The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence. PLoS Pathogens, 16: e1008645. https://doi.org/10.1371/journal.ppat.1008645

Menegatti C; Lourenzon VB; Rodriguez-Hernandez DC; Melo WGP; Ferreira LLG; Nascimento FS; Pupo MT. (2020) Meliponamycins: antimicrobials from stingless bee-associated Streptomyces sp. Journal of Natural Products, 83: 610-616. http://dx.doi.org/10.1021/acs.jnatprod.9b01011

Albiero LR; Andrade MF; Marchi LF; Landi-Librandi AP; Figueiredo-Rinhel ASG; Carvalho CA; Kabeya LM; Oliveira RDR; Azzolini AECS; Pupo MT; Emery FS; Lucisano-Valim YM. (2020) Immunomodulating action of the 3-Phenylcoumarin derivative 6,7-dihydroxy-3-[3’,4’-methylenedioxyphenyl]-coumarin in neutrophils from patients with rheumatoid arthritis and in rats with acute joint inflammation. Inflammation Research, 69: 115-130. http://dx.doi.org/10.1007/s00011-019-01298-w

Batista JH; Leal FC; Fukuda TTH; Diniz JA; Almeida F; Pupo MT; Silva Neto JF. (2020) Interplay between two quorum sensing regulated pathways, violacein biosynthesis and VacJ/Yrb, dictates outer membrane vesicle biogenesis in Chromobacterium violaceum. Environmental Microbiology. 22: 2432-2442. http://dx.doi.org/10.1111/1462-2920.15033

Betancur LA; Forero ALM; Vinchira-Villarraga DM; Cárdenas JD; Romero-Otero A; Chagas FO; Pupo MT; Castellanos L; Ramos FA. (2020) NMR-Based metabolic profiling to follow the production of anti-phytopathogenic compounds in the culture of the marine strain Streptomyces sp. PNM-9. Microbiological Research, 239: 126507. http://dx.doi.org/10.1016/j.micres.2020.126507

 

2019

Brunetti AE; Lyra ML; Melo WGP; Andrade LE; Palacios-Rodriguez P; Prado BM; Haddad CFB; Pupo MT; Lopes, NP. (2019) Symbiotic skin bacteria as a source for sex-specific scents in frogs. Proceedings of the National Academy of Sciences of the United States of America, 116: 2124-2129. http://dx.doi.org/10.1073/pnas.1806834116

Chevrette MG; Carlson CM; Ortega HE; Thomas C; Ananiev GE; Barns KJ; Book AJ; Cagnazzo J; Carlos C; Flanigan W; Grubbs KJ; Horn HA; Hoffmann FM; Klassen JL; Knack JJ; Lewin GR; McDonald BR; Muller L; Melo WGP; Pinto-Tomás AA; Schmitz A; Wendt-Pienkowski E; Wildman S; Zhao M; Zhang F; Bugni TS; Andes DR; Pupo MT; Currie CR. (2019) The antimicrobial potential of Streptomyces from insect microbiomes. Nature Communications 10: article number 516. https://doi.org/10.1038/s41467-019-08438-0

Melo WGP; Pereira CF; Fukuda TTH; Pupo MT. (2019) Interações simbióticas entre micro-organismos e insetos. Revista Recursos Genéticos News - RG News, 5: 48-56.

Rodriguez-Hernandez D; Melo WGP; Menegatti C; lourenzon VB; Nascimento FS; Pupo MT. (2019) Actinobacteria associated with stingless bee biosynthesize bioactive polyketides against bacterial pathogen. New Journal of Chemistry, 43: 10109-10117. http://dx.doi.org/10.1039/C9NJ01619H

Ortega HE; Batista JM; Melo WGP; Paula GT; Pupo MT. (2019) Structure and absolute configuration of secondary metabolites from two strains of Streptomyces chartreusis associated with Attine ants. Journal of the Brazilian Chemical Society, 30: 2672-2680. http://dx.doi.org/10.21577/0103-5053.20190194

Paludo CR; Pishchany G; Andrade-Dominguez A; Silva-Junior EA; Menezes C; Nascimento FS; Currie CR; Kolter R; Clardy J; Pupo MT.(2019) Microbial community modulates growth of symbiotic fungus required for stingless bee metamorphosis. PLoS One, 14: e0219696. http://dx.doi.org/10.1371/journal.pone.0219696

Ortega HE; Ferreira LLG; Melo WGP; De Oliveira AL; Alvarenga RFR; Lopes NP; Bugni TS; Andricopulo AD; Pupo MT. (2019) Antifungal compounds from Streptomyces associated with Attine ants also inhibit Leishmania donovani. PLoS Neglected Tropical Diseases, 13: e0007643. http://dx.doi.org/10.1371/journal.pntd.0007643

 

2018

Chagas FO; Pessotti RC; Caraballo-Rodriguez AM; Pupo MT. (2018) Chemical signaling involved in plant-microbe interactions. Chemical Society Reviews, 47: 1652-1704. http://dx.doi.org/10.1039/C7CS00343A

Andrade MF; Kabeya LM; Bortot LO; Dos Santos GB; Santos EOL; Albiero LR; Figueiredo-Rinhel ASG; Carvalho CA; Azzolini AECS; Caliri A; Pupo MT; Emery FS; Lucisano-Valim Y M. (2018) The 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3-,4--methylenedioxyphenyl]-coumarin downmodulates the FcγR- and CR-mediated oxidative metabolism and elastase release in human neutrophils: Possible mechanisms underlying inhibition of the formation and release of neutrophil extracellular traps. Free Radical Biology and Medicine, 115: 421-435. http://dx.doi.org/10.1016/j.freeradbiomed.2017.12.012

Paludo CR; Menezes C; Silva-Junior EA; Vollet-Neto A; Andrade-Dominguez A; Pishchany G; Khadempour L; Nascimento FS; Currie CR; Kolter R; Clardy J; Pupo MT. (2018) Stingless bee larvae require fungal steroid to pupate. Scientific Reports, 8: 1122. http://dx.doi.org/10.1038/s41598-018-19583-9

Silva-Junior EA; Ruzzini AC; Paludo CR; Nascimento FS; Currie CR; Clardy J; Pupo MT. (2018) Pyrazines from bacteria and ants: convergent chemistry within an ecological niche. Scientific Reports, 8: 2595. http://dx.doi.org/10.1038/s41598-018-20953-6

Chagas FO; Pupo, MT. (2018) Chemical interaction of endophytic fungi and actinobacteria from Lychnophora ericoides in co-cultures. Microbiological Research, 212-213: 10-16. http://dx.doi.org/10.1016/j.micres.2018.04.005

Almeida MO; Lopes AA; Roberto PG; Bertoni BW; Pupo MT. (2018) Unveiling the fungal biotransformation of hydralazine using 13C-precursor. Phytochemistry Letters, 26: 55-59. http://dx.doi.org/10.1016/j.phytol.2018.05.018

Silva G; Suarez I; Conti R; Pinedo C; Moraga J; Barua J; De Oliveira AL; Aleu J; Duran R; Macias-Sanchez AJ; Hanson JR; Pupo MT; Hernández-Galán R; Colado IG. (2018) structural and biosynthetic studies on eremophilenols related to the phytoalexin capsidiol, produced by Botrytis cinerea. Phytochemistry, 154: 10-18. http://dx.doi.org/10.1016/j.phytochem.2018.06.010

Li H; Sosa-Calvo J; Horn HA; Pupo MT; Clardy J; Rabeling C; Schultz TR; Currie CR. (2018) Convergent evolution of complex structures for ant-bacterial defensive symbiosis in fungus-farming ants. Proceedings of the National Academy of Sciences of the United States of America, 115: 10720-10725. http://dx.doi.org/10.1073/pnas.1809332115

Menegatti C; Melo WGP; Carrao DB; Oliveira ARM; Nascimento FS; Lopes NP; Pupo MT. (2018) Paenibacillus Polymyxa associated with the stingless bee Melipona scutellaris produces antimicrobial compounds against entomopathogens. Journal of Chemical Ecology, 44: 1158-1169. http://dx.doi.org/10.1007/s10886-018-1028-z

Menezes C; Paludo CR; Pupo MT. (2018) A Review of the Artificial Diets Used as Pot-Pollen Substitutes. In: Vit P; Pedro SRM; Roubik D (Org.). Pot-Pollen in stingless bee melittology. 1ed.New York: Springer International Publishing, 1: 253-262.

 

2017

Chagas FO; Caraballo-Rodriguez AM; Dorrestein P; Pupo MT. (2017) Expanding the chemical repertoire of the endophyte Streptomyces albospinus RLe7 reveals Amphotericin B as an inducer of a fungal phenotype. Journal of Natural Products, 80: 1302-1309. http://dx.doi.org/10.1021/acs.jnatprod.6b00870

Pupo MT; Currie CR; Clardy J. (2017) Microbial symbionts of insects are the focus of the first International Cooperative Biodiversity Group (ICBG) in Brazil. Journal of the Brazilian Chemical Society, 28: 393-401. http://dx.doi.org/10.21577/0103-5053.20160284

Silva-Junior EA; Paludo CR; Valadares LCA; Lopes NP; Nascimento FS; Pupo MT. (2017) Aflatoxins produced by Aspergillus nomius ASR3, a pathogen isolated from the Leaf-Cutter ant Atta Sexdens rubropilosa. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, 27: 529-532. http://dx.doi.org/10.1016/j.bjp.2017.05.001

Caraballo-Rodriguez AM; Dorrestein PC; Pupo MT. (2017) Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides. Scientific Reports, 7: 5373. http://dx.doi.org/10.1038/s41598-017-05532-5

Caraballo-Rodriguez AM; Mayor CA; Chagas FO; PUPO, MT. (2017) Amphotericin B as an inducer of Griseofulvin-containing Guttate In the endophytic fungus Xylaria cubensis Fle9. Chemoecology, 27: 177-185. http://dx.doi.org/10.1007/s00049-017-0243-3

Ortega HE; Batista JM; Melo WGP; Clardy J; Pupo MT. (2017) Absolute configurations of Griseorhodins A and C. Tetrahedron Letters, 58: 4721-4723. http://dx.doi.org/10.1016/j.tetlet.2017.11.008

Silva-Junior EA; Paludo CR; Gouvea DR; Kato MJ; Furtado NAJC; LopesNP; Vessecchi R; Pupo MT. (2017) Gas-phase fragmentation of protonated Piplartine and its fungal metabolites using tandem mass spectrometry and computational chemistry. Journal of Mass Spectrometry, 52: 517-525. http://dx.doi.org/10.1002/jms.3955

Paludo CR; Silva-Junior EA; Silva EO; Vessecchi R; Lopes NP; Pupo MT; Emery FS; Goncalves NS; Santos RA; Furtado NAJC. (2017) Inactivation of β-Lapachone cytotoxicity by filamentous fungi that mimic the human blood metabolism. European Journal of Drug Metabolism and Pharmacokinetics, 42: 213-220. http://dx.doi.org/10.1007/s13318-016-0337-2

Pessotti RC; Caraballo-Rodriguez AM; Ortega HE; Pupo MT. (2017) Terrestrial microbial natural products discovery guided by symbiotic interactions and revealed by advanced analytical methods. In: Newman DJ; Cragg GM.; Grothaus PG. (Org.). Chemical Biology of Natural Products. 1ed.: CRC Press, 1: 161-188.

 

2016

Conti R; Chagas FO; Caraballo-Rodriguez AM; Melo WGP; Nascimento AM; Cavalcanti BC; Moraes MO; Pessoa CO; Costa-Lotuffo LV; Krogh R; Andricopulo AD; Lopes NP; Pupo MT. (2016) Endophytic actinobacteria from the Brazilian medicinal plant Lychnophora ericoides Mart. and the biological potential of their secondary metabolites. Chemistry & Biodiversity, 13: 727-736. http://dx.doi.org/10.1002/cbdv.201500225

Santos GB; Krogh R; Magalhaes LG; Andricopulo AD; Pupo MT; Emery FS. (2016) Semisynthesis of new aphidicolin derivatives with high activity against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry Letters, 26: 1205-1208. http://dx.doi.org/10.1016/j.bmcl.2016.01.033

Chagas FO; Ruzzini AC; Bacha LV; Samborskyy M; Conti R; Pessotti RC; Oliveira LG; Clardy J; Pupo MT. (2016) Genome sequence of Streptomyces sp. strain RTd22, an endophyte of the Mexican Sunflower. Genome Announcements, 4: e00693-16. http://dx.doi.org/10.1128/genomeA.00693-16.

Chagas FO; Dias LG; Pupo MT. (2016) New perylenequinone derivatives from the endophytic fungus Alternaria tenuissima SS77. Tetrahedron Letters, 57: 3185-3189. http://dx.doi.org/10.1016/j.tetlet.2016.06.035

Lopes AA; Pina ES; Nader TS; Costa FBDa; Pereira AMS; Pupo MT. (2016) Biosynthesis of (-)-ent-kaurenoic acid in Smallanthus sonchifolius and its effect against microbial biofilms. Phytochemistry Letters, 18: 162-167. http://dx.doi.org/10.1016/j.phytol.2016.10.011

Paludo CR; Ruzzini AC; Silva-Junior EA; Pishchany G; Currie CR; Nascimento FS; Kolter R; Clardy J; Pupo MT. (2016) Whole-genome sequence of Bacillus sp. SDLI1 isolated from the social bee Scaptotrigona depilis. Genome Announcements, 4: e00174-16. http://dx.doi.org/10.1128/genomeA.00174-16

 

2015

Charlop-Powers Z; Owen JG; Reddy BVB; Ternei MA; Guimarães DO; De Frias UA; Pupo MT; Seepe P; Feng Z; Brady SF. (2015) Global biogeographic sampling of bacterial secondary metabolism. eLife, 4: e05048. http://dx.doi.org/10.7554/eLife.05048

Barth T; Hilario VC; Rocha BA; Furtado NAJC; Pupo MT; Oliveira ARM. (2015) Asymmetric sulfoxidation of Albendazole to Ricobendazole by fungi: Effect of pH. Química Nova, 944-947. http://dx.doi.org/10.5935/0100-4042.20150102

Bortoleto MA; Bocato MZ; Pupo MT; Gaitani CM; Oliveira ARM. (2015) Coupling DLLME-CE for the stereoselective analysis of Venlafaxine and Its main metabolites after biotransformation by fungi. Journal of the Brazilian Chemical Society, 26: 1956-1966. http://dx.doi.org/10.5935/0103-5053.20150174

De Felício R; Pavão G; De Oliveira AL; Erbert C; Conti R; Pupo MT; Furtado N; Ferreira E; Costa-Lotufo L; Young MC; Yokoya N; Debonsi H. (2015) Antibacterial, antifungal and cytotoxic activities exhibited by endophytic fungi from the brazilian marine red alga Bostrychia tenella (Ceramiales). Revista Brasileira de Farmacognosia, 25: 641-650. http://dx.doi.org/10.1016/j.bjp.2015.08.003

Chagas FO; Caraballo-Rodriguez AM; Pupo MT. (2015) Endophytic fungi as a source of novel metabolites. In: Susanne Zeilinger; Juan-Francisco Martín; Carlos García-Estrada. (Org.). Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, volume 2. 1ed. New York: Springer, 2: 123-176.

 

2014

Andrioli WJ; Conti R; Araújo MJ; Zanasi R; Cavalcanti BC; Manfrim V; Toledo JS; Tedesco D; De Moraes MO; Pessoa C; Cruz AK; Bertucci C; Sabino J; Nanayakkara DNP; Pupo MT; Bastos JK. (2014) Mycoleptones A-C and polyketides from the endophyte Mycoleptodiscus indicus. Journal of Natural Products, 77: 140103112839008-78. http://dx.doi.org/10.1021/np4006822

Marques LMM; Silva-Junior EADA; Gouvea DR; Vessecchi R; Pupo, MT; Lopes NP; Kato MJ; Oliveira A RMDe . In vitro metabolism of the alkaloid Piplartine by rat liver microsomes. Journal of Pharmaceutical and Biomedical Analysis, 95: 113-120. http://dx.doi.org/10.1016/j.jpba.2014.02.020

Gallo M; Falso M; Balem F; Menezes D; Rocha N; Balachandran R; Sturgeon T; Pupo M; Day B. (2014) The anti-promyelocytic leukemia mode of action of two endophytic secondary metabolites unveiled by a proteomic approach. Planta Medica, 80: 473-481. http://dx.doi.org/10.1055/s-0034-1368301

Tuiche MV; Lopes AA; Silva DB; Lopes, NP; Pupo MT. (2014) Direct MALDI-TOF/TOF analyses of unnatural beauvericins produced by the endophytic fungus Fusarium oxysporum SS46. Revista Brasileira de Farmacognosia, 24: 433-438. http://dx.doi.org/10.1016/j.bjp.2014.06.002

Bocato MZ; Bortoleto MA; Pupo MT; Oliveira ARM. (2014) A new enantioselective CE method for determination of oxcarbazepine and licarbazepine after fungal biotransformation. Electrophoresis, 35: 2877-2884. http://dx.doi.org/10.1002/elps.201400137

Santos GB; Almeida MO; Cardoso IA; Manfrim V; Chagas FO; Toledo JS; Pinzan C; Araujo AS; Cruz AK; Pupo MT; Emery FS. (2014) The semisynthetic landscape of aphidicolin: inspiration towards leishmanicidal compounds. Journal of the Brazilian Chemical Society, 25: 1885-1899. http://dx.doi.org/10.5935/0103-5053.20140162

 

2013

Lopes AA; Pina ES; Silva DB; Pereira AMS; Silva MFGF; Costa FBDa; Lopes NP; Pupo MT. (2013) A Biosynthetic pathway of sesquiterpene lactones in Smallanthus sonchifolius and their localization in leaf tissues by MALDI Imaging. Chemical Communications, 49: 9989-9991. http://dx.doi.org/10.1039/c3cc46213g

Messiano GB; Santos RAS; Ferreira LS; Simoes RA; Kato MJ; Lopes NP; Pupo MT; Oliveira ARM. (2013) In vitro metabolism study of the promising anticancer agent the lignan (-)-grandisin. Journal of Pharmaceutical and Biomedical Analysis, 72: 240-244. http://dx.doi.org/10.1016/j.jpba.2012.08.028

Barth T; Aleu-Casatejada J; Pupo MT; Bonato PS; Collado IG. HPLC analysis of midodrine and Desglymidodrine in culture medium: evaluation of static and shaken conditions on the biotransformation by fungi. Journal of Chromatographic Science, 51: 460-467. http://dx.doi.org/10.1093/chromsci/bms163

Santos MS; Lama MPFM; Deliberto LA; Emery FS; Pupo MT; Naal RMZG. (2013) In situ screening of 3-arylcoumarin derivatives reveals new inhibitors of mast cell degranulation. Archives of Pharmacal Research, 36: 731-738. http://dx.doi.org/10.1007/s12272-013-0084-8

Andrade MF; Kabeya LM; Azzolini AECS; Santos EOL; Figueiredo-Rinhel ASG; Paris MRP; Emery FS; Pupo MT; Lucisano-Valim YM. (2013) 3-Phenylcoumarin derivatives selectively modulate different steps of reactive oxygen species production by immune complex-stimulated human neutrophils. International Immunopharmacology, 15: 387-394. http://dx.doi.org/10.1016/j.intimp.2013.01.001

Fortes SS; Barth T; Furtado NAJC; Pupo MT; De Gaitani CM; De Oliveira ARM. (2013) Evaluation of dispersive liquid-liquid microextraction in the stereoselective determination of cetirizine following the fungal biotransformation of hydroxyzine and analysis by capillary electrophoresis. Talanta (Oxford), 116: 743-752. http://dx.doi.org/10.1016/j.talanta.2013.07.062

Arakawa NS; Gobbo Neto L; Ambrosio SR; Antonucci GA; Sampaio SV; Pupo MT; Said S; Schmidt TJ; DaCosta FB. (2013) Unusual biotransformation products of the sesquiterpene lactone budlein A by Aspergillus species. Phytochemistry, 6: 92-100. http://dx.doi.org/10.1016/j.phytochem.2013.09.022

Paludo CR; Silva-Junior EA; Santos RA; Pupo MT; Emery FS; Furtado NAJC. (2013) Microbial transformation of β-Lapachone to its Glycosides by Cunninghamella elegans ATCC 10028b. Phytochemistry Letters, 6: 657-661. http://dx.doi.org/10.1016/j.phytol.2013.08.014

Oliveira LG; Pupo MT; Vieira PC. (2013) Explorando produtos naturais microbianos nas fronteiras da Química e da Biologia. Química Nova, 36: 1577-1586. http://dx.doi.org/10.1590/S0100-40422013001000015

Chagas FO; Dias LG; Pupo MT. (2013) A mixed culture of endophytic fungi increases production of antifungal polyketides. Journal of Chemical Ecology, 39: 1335-1342. http://dx.doi.org/10.1007/s10886-013-0351-7

Silva EO; Andrioli WJ; Lopes AA; Pupo MT; Bastos JK. (2013) Isolation of the terpestacin from the endophytic fungus Drechslera ravenelii. International Journal of Nanobiotechnology and Pharmacy, 2013: 2-7.

 

2012

Andrioli WJ; Silva TM; da Silva VB; Damásio ARL; Maller A; Conti R; Jorge JA; Araújo JM; Silva CHTP; Pupo MT; Polizeli MLTM; Bastos JK. (2012) The fungal metabolite eugenitin as additive for Aspergillus niveus glucoamylase activation. Journal of Molecular Catalysis. B, Enzymatic, 74: 156-161. http://dx.doi.org/10.1016/j.molcatb.2011.08.003

Hilario VC; Carrao DB; Barth T; Borges KB; Furtado NAJC; Pupo MT; Oliveira ARM. (2012) Assessment of the stereoselective fungal biotransformation of Albendazole and its analysis by HPLC in polar organic mode. Journal of Pharmaceutical and Biomedical Analysis, 61: 100-107. http://dx.doi.org/10.1016/j.jpba.2011.12.012

Andrioli WJ; Santos MS; da Silva VB; Oliveira R; Chagas-De-Paula D; Jorge JA; Furtado NAJC; Pupo MT; Silva CHTP; Naal RMZG; Bastos JK. (2012) Delta-lactam derivative from thermophilic soil fungus exhibits in vitro anti-allergic activity. Natural Product Research, 26: 2168-2175. http://dx.doi.org/10.1080/14786419.2011.647020

Guimarães DO; Lopes NP; Pupo MT. (2012) Meroterpenes isolated from the endophytic fungus Guignardia mangiferae. Phytochemistry Letters, 5: 519-523. http://dx.doi.org/10.1016/j.phytol.2012.05.004

Erbert C; Lopes AA; Yokoya NS; Furtado NAJC; Conti R; Pupo MT; Lopes JLC; Debonsi HM. (2012) Antibacterial compound from the endophytic fungus Phomopsis longicolla isolated from the tropical red Seaweed Bostrychia radicans. Botanica Marina, 55: 435-440. http://dx.doi.org/10.1515/bot-2011-0023

Conti R; Guimarães DO; Pupo MT. (2012) Aprendendo com as interações da natureza: microrganismos simbiontes como fontes de produtos naturais bioativos. Ciência e Cultura, 64: 43-47.

Nascimento AM; Conti R; Turatti ICC; Cavalcanti BC; Costa-Lotuffo LV; Pessoa C; Moraes MO; Manfrim V; Toledo JS; Cruz AK; Pupo MT. (2012) Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum. Revista Brasileira de Farmacognosia, 22: 1276-1281.  http://dx.doi.org/10.1590/S0102-695X2012005000106

Barth T; Conti R; Pupo MT; Okano LT; Bonato PS. (2012) Chiral HPLC analysis of Donepezil, 5-O-Desmethyl Donepezil and 6-O-Desmethyl Donepezil in culture medium: application to fungal biotransformation studies. Analytical and Bioanalytical Chemistry, 404: 257-266. http://dx.doi.org/10.1007/s00216-012-6107-3

Bocato MZ; Simões RA; Calixto LA; De Gaitani CM; Pupo MT; De Oliveira ARM. (2012) Solid phase microextraction and LC MS/MS for the determination of Paliperidone after stereoselective fungal biotransformation of Risperidone. Analytica Chimica Acta, 742: 80-89. http://dx.doi.org/10.1016/j.aca.2012.05.056

Rocha BA; Pupo MT; Antonucci GA; Sampaio SV; Melo Alves Paiva R; Said S; Gobbo-Neto L; Costa FB. (2012) Microbial transformation of the sesquiterpene lactone Tagitinin C by the fungus Aspergillus terreus. Journal of Industrial Microbiology and Biotechnology, 39: 1719-1724. http://dx.doi.org/10.1007/s10295-012-1165-2

Lopes AA; Guimarães DO; Pupo MT. (2012) Quando os micro-organismos salvam vidas: Seres diminutos a serviço da produção de medicamentos. In: Alicia Ivanissevich; Angelo da Cunha Pinto. (Org.). Química Hoje. 1ed., Rio de Janeiro: Instituto CIência Hoje, 1: 98-107.

 

2011

Lopes AA; Pupo MT. Biosynthesis of Aphidicolin proceeds via the Mevalonate pathway in the endophytic Fungus Nigrospora sphaerica. Journal of the Brazilian Chemical Society, 22: 80-85. http://dx.doi.org/10.1590/S0103-50532011000100010

Borges KB; Oliveira ARM; Barth T; Jabor VAP; Pupo MT. (2011) LC-MS/MS Determination of Ibuprofen, 2-Hydroxyibuprofen Enantiomers and Carboxyibuprofen stereoisomers for application in biotransformation studies employing endophytic fungi. Analytical and Bioanalytical Chemistry, 399: 915-925. http://dx.doi.org/10.1007/s00216-010-4329-9

Borges KB; Sánchez AJM; Pupo MT; Bonato PS; Collado IG. (2011) Fast HPLC analysis of Omeprazole, 5-Hydroxyomeprazole and Omeprazole Sulphone in liquid culture medium using a monolithic column for application in biotransformation studies employing fungi. Journal of the Brazilian Chemical Society, 22: 1140-1149. http://dx.doi.org/10.1590/S0103-50532011000600020

Carrao DB; Borges KB; Barth T; Pupo MT; Bonato PS; Oliveira ARM. (2011) Capillary electrophoresis and hollow fiber liquid-phase microextraction for the enantioselective determination of Albendazole Sulfoxide after biotransformation of Albendazole by an endophytic fungus. Electrophoresis, 32: 2746-2756. http://dx.doi.org/10.1002/elps.201000658

Borges KB; Bonato PS; Pupo MT. (2011) Enantioselective biotransformation of Propranolol to the active metabolite 4-Hydroxypropranolol by endophytic fungi. Química Nova, 34: 1354-1357. http://dx.doi.org/10.1590/S0100-40422011000800011

Borges WS; Mancilla G; Guimarães DO; Duran-Patron R; Colado IG; Pupo MT. (2011) Azaphilones from the endophyte Chaetomium globosum. Journal of Natural Products, 74: 1182-1187. http://dx.doi.org/10.1021/np200110f

Jesus LI; Albuquerque NCP; Borges KB; Simoes RA; Calixto LA; Furtado NAJC; Gaitani CM; Pupo MT; Oliveira ARM. (2011) Enantioselective fungal biotransformation of Risperidone in liquid culture medium by capillary electrophoresis and hollow fiber liquid-phase microextraction. Electrophoresis, 32: 2765-2775. http://dx.doi.org/10.1002/elps.201100328

Barth T; Simoes RA; Pupo MT; Okano LT; Bonato PS. (2011) Stereoselective liquid chromatographic determination of 1 -Oxobufuralol and 1 -Hydroxybufuralol in rat liver microsomal fraction using hollow-fiber liquid-phase microextraction for sample preparation. Journal of Separation Science, 34: 3578-3586. http://dx.doi.org/10.1002/jssc.201100464

Lopes AA; Guimarães DO; Pupo MT. (2011) Quando os micro-organismos salvam vidas. Ciência Hoje, 286: 36-41.

Borges WS; Mancilla G; Guimaraes DO; Duran-Patron R; Collado IG; Pupo MT. (2011) Correction to Azaphilones from the endophyte. Journal of Natural Products, 74: 110819151828093-2028. http://dx.doi.org/10.1021/np200556p

 

2010

Guimarães DO; Momesso LS; Pupo MT. (2010) Antibióticos: importância terapêutica e perspectivas para a descoberta e desenvolvimento de novos agentes. Química Nova, 33: 667-679. http://dx.doi.org/10.1590/S0100-40422010000300035

Barth T; Pupo MT; Borges KB; Okano LT; Bonato PS. (2010) Stereoselective determination of Midodrine and Desglymidodrine in culture medium: application to a biotransformation study employing endophytic fungi. Electrophoresis, 31: 1521-1528. http://dx.doi.org/10.1002/elps.200900685

Braun GH; Ramos HP; Pupo MT; Said S. (2010) Antimicrobial activity from endophytic fungi Arthrinium state of Apiospora montagbei Sacc. and Papulaspora immersa. Brazilian Archives of Biology and Technology, 53: 629-632. http://dx.doi.org/10.1590/S1516-89132010000300017

Guimarães DO; Borges WS; Vieira NJ; Oliveira LFDE; Silva CHTDPDa; Lopes NP; Dias LG; Duran-Patron R; Collado IG; Pupo MT. (2010) Diketopiperazines produced by endophytic fungi found in association with two Asteraceae species. Phytochemistry, 71: 1423-1429. http://dx.doi.org/10.1016/j.phytochem.2010.05.012

Borges KB; Sánchez AJM; Pupo MT; Bonato PS; Collado IG. (2010) Ultra fast gradient method for Omeprazole analysis using a monolithic column: assay development, validation and application to the quality control of Omeprazole enteric coated pellets. Journal of AOAC International, 93: 1811-1820. 

Gallo MBC; Cavalcanti BC; Barros FWA; Moraes MO; Costa-Lotuffo LV; Pessoa C; Bastos JK; Pupo MT. (2010) Chemical constituents of Papulaspora immersa, an endophyte from Smallanthus sonchifolius (Asteraceae), and their cytotoxic activity. Chemistry & Biodiversity, 7: 2941-2950. http://dx.doi.org/10.1002/cbdv.201000011

 

2009

Gallo MBC; Chagas FO; Almeida MO; Macedo CC; Cavalcanti BC; Barros FWA; Moraes MO; Costa-Lotuffo LV; Pessoa CO; Bastos JK; Pupo MT. (2009) Endophytic fungi found in association with Smallanthus sonchifolius (Asteraceae) as resourceful producers of cytotoxic bioactive natural products. Journal of Basic Microbiology, 49: 142-151. http://dx.doi.org/10.1002/jobm.200800093

Guimarães DO; Borges KB; Bonato PS; Pupo MT. (2009) A simple method for the quantitative analysis of Tyrosol by HPLC in liquid Czapek cultures from endophytic fungi. Journal of the Brazilian Chemical Society, 20: 188-194. http://dx.doi.org/10.1590/S0103-50532009000100028

Verza M; Arakawa NS; Lopes NP; Kato MJ; Pupo MT; Said S; Carvalho I. (2009) Biotransformation of a Tetrahydrofuran lignan by the endophytic fungus Phomopsis sp. Journal of the Brazilian Chemical Society, 20: 195-200. http://dx.doi.org/10.1590/S0103-50532009000100029

Borges KB; Pupo MT; Freitas LAP; Bonato PS. (2009) Box-Behnken design for the optimization of an enantioselective method for the simultaneous analysis of Propranolol and 4-Hydroxypropranolol by capillary electrophoresis. Electrophoresis, 30: 2874-2881. http://dx.doi.org/10.1002/elps.200800821

Borges KB; Borges WS; Duran-Patron R; Pupo MT; Bonato PS; Collado IG. (2009) Stereoselective biotransformations using fungi as biocatalysts. Tetrahedron. Asymmetry, 20: 385-397. http://dx.doi.org/10.1016/j.tetasy.2009.02.009

Yuan H; Pupo MT; Blois J; Smith A; Weissleder R; Clardy J; Josephson. (2009) A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorganic & Medicinal Chemistry Letters, 19: 4223-4227. http://dx.doi.org/10.1016/j.bmcl.2009.05.105

Borges WS; Borges KB; Bonato PS; Said S; Pupo MT. (2009) Endophytic fungi: natural products, enzymes and biotransformation. Current Organic Chemistry, 13: 1137-1163. http://dx.doi.org/10.2174/138527209788921783

Borges KB; Pupo MT; Bonato PS. (2009) Enantioselective analysis of Propranolol and 4-Hydroxypropranolol by capillary electrophoresis with application to biotransformation studies employing endophytic fungi. Electrophoresis, 30: 3910-3917. http://dx.doi.org/10.1002/elps.200900216

Borges KB; Okano LT; Pupo MT; Bonato PS. (2009) Enantioselective analysis of Fluoxetine and Norfluoxetine by HPLC in culture medium for application in biotransformation studies employing fungi. Chromatographia, 70: 1335-1342. http://dx.doi.org/10.1365/s10337-009-1321-7

 

2008

Borges KB; Borges WS; Pupo MT; Bonato PS. (2008) Stereoselective analysis of Thioridazine-2-Sulfoxide and Thioridazine-5-Sulfoxide: an investigation of Rac-Thioridazine biotransformation by some endophytic fungi. Journal of Pharmaceutical and Biomedical Analysis, 46: 945-952. http://dx.doi.org/10.1016/j.jpba.2007.05.018

Kabeya LM; Silva CHTPDa; Kanashiro A; Campos JM; Azzolini AECS; Polizello ACM; Pupo MT; Lucisano-Valim YM. (2008) Inhibition of immune complex-mediated neutrophil oxidative metabolism: a pharmacophore model for 3-Phenyl Coumarin derivatives using GRIND-Based 3D-QSAR and 2D-QSAR. European Journal of Medicinal Chemistry, 43: 996-1007. http://dx.doi.org/10.1016/j.ejmech.2007.07.003

Guimarães DO; Borges WS; Kawano CY; Ribeiro PH; Goldman GH; Nomizo A; Thiemann OH; Oliva G; Lopes NP; Pupo MT. (2008) Biological activities from extracts of endophytic fungi isolated from Viguiera arenaria and Tithonia diversifolia. FEMS Immunology and Medical Microbiology, 52: 134-144. http://dx.doi.org/10.1111/j.1574-695X.2007.00354.x

Momesso LS; Kawano CY; Ribeiro PH; Nomizo A; Goldman GH; Pupo MT. (2008) Chaetoglobosinas produzidas por Chaetomium globosum, fungo endofítico associado a Viguiera robusta Gardn. (Asteraceae). Química Nova, 31: 1680-1685. http://dx.doi.org/10.1590/S0100-40422008000700015

Rafael JA; Arakawa NS; Braun GH; Ramos HP; Foster VC; Costa FBDa; Pupo MT; Said S. (2008) Biodiversidade de fungos e seu potencial como agentes produtores de fármacos. Microbiologia in Foco, 2: 12-17.

Gallo MBC; Guimarães DO; Momesso LDAS; Pupo MT. (2008) Natural products from endophytic fungi. In: Ratul Saikai; Rajib L. Bezbaruah; Tarun Ch. Bora. (Org.). Microbial Biotechnology. New Delhi: New India Publishing Agency: 139-168.

Pupo MT; Borges KB; BORGES WS; Bonato PS. (2008) Fungal biotransformations: a powerful tool in drug metabolism studies. In: Ratul Saikai; Rajib L. Bezbaruah; Tarun Ch. Bora. (Org.). Microbial Biotechnology. New Delhi: New India Publishing Agency: 47-66.

 

2007

Kabeya LM; Marchi AA; Kanashiro A; Lopes NP; Silva CHTPDa; Pupo MT; Lucisano-Valim YM. (2007) Inhibition of horseradish peroxidase catalytic activity by new 3-Phenylcoumarin derivatives: synthesis and structure-activity relationships. Bioorganic & Medicinal Chemistry, 15: 1516-1524. http://dx.doi.org/10.1016/j.bmc.2006.10.068

Pupo MT; Gallo MBC; Vieira PC. (2007) Biologia química: uma estratégia moderna para a pesquisa em produtos naturais. Química Nova, 30: 1446-1455. http://dx.doi.org/10.1590/S0100-40422007000600014

Borges KB; Borges WS; Pupo MT; Bonato PS. (2007) Endophytic fungi as models for the stereoselective biotransformation of Thioridazine. Applied Microbiology and Biotechnology, 77: 669-674. http://dx.doi.org/10.1007/s00253-007-1171-x

Gallo MBC; Pupo MT; Bastos JK; Nunes AS; Cavalcanti BC; Moraes MO; Costa-Lotuffo LV; Pessoa CO. (2007) Atividade citotóxica de extratos de fungos Endofíticos isolados de Smallanthus sonchifolius. Revista Brasileira de Biociências, 5: 402-404.

 

2006

Elias BC; Said S; Albuquerque S; Pupo MT. (2006) The influence of culture conditions on the biosynthesis of secondary metabolites by Penicillium verrucosum Dierck. Microbiological Research, 161; 3: 273-280. http://dx.doi.org/10.1016/j.micres.2005.10.003

Borges WS; Pupo MT. (2006) Novel Anthraquinone derivatives produced by Phoma sorghina, an endophyte found in association with the medicinal plant Tithonia diversifolia (Asteraceae). Journal of the Brazilian Chemical Society, 17: 929-934. http://dx.doi.org/10.1590/S0103-50532006000500017

Pupo MT; Guimarães DO; Furtado NAJC; BORGES WS. (2006) Microbial natural products: a promising source of bioactive compounds. In: Carlton A. Taft. (Org.). Modern Biotechnology in Medicinal Chemistry and Industry. Kerala: Research Signpost: 51-78.

Carvalho I; Pupo MT; Borges ÁDL; Bernardes LSC. (2006) A laboratory course in medicinal chemistry introducing molecular modeling. In: Antonio Monge; C. Robin Ganellin. (Org.). IUPAC - Practical Studies for Medicinal Chemistry: An integrating Approach for Developing Countries. USA: Research Triangle Park, III; 2: 1-24.

 

2005

Furtado NAJC; Pupo MT; Carvalho I; Campo VL; Duarte MCT; Bastos JK. (2005) Diketopiperazines produced by an Aspergillus fumigatus brazilian strain. Journal of the Brazilian Chemical Society, 16; 6B: 1448-1453. http://dx.doi.org/10.1590/S0103-50532005000800026

 

2004

Garcia silva M; Furtado NAJC; Pupo MT; Fonseca MJV; Said S; Silva Filho AA; Bastos JK. (2004) Antibacterial activity from Penicillium corylophilum Dierckx. Microbiological Research, 159;.4: 317-322. http://dx.doi.org/10.1016/j.micres.2004.06.003

Marchi AA; Castilho MS; Nascimento PGBD; Archanjo FC; Ponte G; Oliva G; Pupo MT. (2004) New 3-Piperonylcoumarins as inhibitors of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase (gGAPDH) from Trypanosoma cruzi. Bioorganic & Medicinal Chemistry, 12; 18: 4823-4833. http://dx.doi.org/10.1016/j.bmc.2004.07.018

Leitao A; Andricopulo AD; Oliva G; Pupo MT; Marchi AA; Vieira PC; Silva MFGF; Sá MM; Moraes VRS; Montanari CA. (2004) Structure-activity relationships of novel inhibitors of Glyceraldehyde-3-Phosphate Dehydrogenase. Bioorganic & Medicinal Chemistry Letters, 14: 2199-2204. http://dx.doi.org/10.1016/j.bmcl.2004.02.025

Nihei K; Konno K; Bernardes LSC; Lopes NP; Albuquerque S; Carvalho I; Pupo MT; Martins RCC; Kato MJ. (2004) Synthesis of trypanocidal Tetrahydrofuran lignans. ARKIVOC, 2004; vi: 112-126.

 

2003

Carvalho I; Pupo MT; Borges ÁDL; Bernardes LSC. (2003) Introdução à modelagem molecular de fármacos no curso experimental de Química Farmacêutica. Química Nova, 26; 3: 428-438. http://dx.doi.org/10.1590/S0100-40422003000300023

Menezes IRA; Lopes JCD; Montanari CA; Oliva G; Pavão F; Castilho MS; Vieira PC; Pupo MT. (2003) 3D QSAR studies on binding affinities of coumarin natural products for glycosomal GAPDH of Trypanosoma cruzi. Journal of Computer-Aided Molecular Design, 17; 5-6: 277-290. http://dx.doi.org/10.1023/A:1026171723068

 

2002

Pavão F; Castilho MS; Pupo MT; Dias RLA; Correa AG; Fernandes JB; Silva MFGF; Mafezoli J; Vieira PC; Oliva G. (2002) Structure of Trypanosoma cruzi glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase complexed with a natural product inhibitor at 1.95 A resolution. FEBS Letters, 520;1-3: 13-17. http://dx.doi.org/10.1016/S0014-5793(02)02700-X

Pupo MT; Adorno MAT; Vieira PC; Fernandes JB; Silva MFGF; Pirani JR. (2002) Terpenoids and steroids from Trichilia species. Journal of the Brazilian Chemical Society, 13; 3: 382-388. http://dx.doi.org/10.1590/S0103-50532002000300014

 

2001

Vieira PC; Mafezoli J; Pupo MT; Fernandes JB; SILVA MFG; Albuquerque S; Oliva G; Pavão F. (2001) Strategies for the isolation and identification of trypanocidal compounds from the Rutales. Pure and Applied Chemistry, 73; 3: 617-622. http://dx.doi.org/10.1351/pac200173030617

 

2000

Tomazela D; Pupo MT; Passador EAP; Silva MFGF; Vieira PC; Fernandes JB; Rodrigues Filho E; Oliva G; Pirani JR. (2000) Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycossomal Glyceraldehyde-3-Phosphate Dehydrogenase-inhibitory activities. Phytochemistry, 55; 6: 643-651. http://dx.doi.org/10.1016/S0031-9422(00)00248-X

 

1998

Pupo MT; Vieira PC; Fernandes JB; Silva MFGF. (1998) Gamma-Lactones from Trichilia claussenii. Phytochemistry, 48; 2: 307-310. http://dx.doi.org/10.1016/S0031-9422(97)01089-3

 

1997

Pupo MT; Vieira PC; Fernandes JB; Silva MFGF; Rodrigues Filho E. (1997) Androstane and pregnane 2beta, 19-hemiketal steroids from Trichilia claussenii. Phytochemistry, 45; 7: 1495-1500. http://dx.doi.org/10.1016/S0031-9422(97)00167-2

 

1996

Pupo MT; Vieira PC; Fernandes JB; Silva MFGF. (1996) A cycloartane triterpenoid and omega-phenyl alkanoic and alkenoic acids from Trichilia claussenii. Phytochemistry, 42; 3: 795-798. http://dx.doi.org/10.1016/0031-9422(95)00969-8.